Genetical improvement of functional herd life in cattle – Possible approaches of gene-assisted selection

Application of methods of molecular genome analysis is discussed as an alternative approach for genetical improvement of functional herd life in cattle. In German dairy cattle population, progress of functional herd life and whole life performance represent a substantial basis for increase of productivity and further improvement of consumer acceptance. Identification of corresponding trait-associated genes and gene variants is an important prerequisite for application of gene-assisted selection approach. In principle, it can be expected that together with genetic progress in fertility, udder health and claw and limbs diseases as the most important culling reasons, also progress in functional herd life will be achieved. Identified candidate genes of these functional traits represent potential candidates for functional herd life. In addition, genes exhibiting genetic variants that are associated with an increased life expectancy are further candidates for functional herd life in cattle. Corresponding genes and gene variants identified in human, mouse and cattle are discussed.

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